Starting today, Amazon EC2 C5d, M5d, M5a, M5ad, R5, R5d, R5a, R5ad, T3, T3a, I3 instances are available in South America (Sao Paulo) region. In addition, C5 will now also be available in new 12xlarge, 24xlarge, and Bare Metal sizes and M5 instances will now be available as Bare Metal in South America (Sao Paulo) region.

from Recent Announcements https://aws.amazon.com/about-aws/whats-new/2019/10/amazon-ec2-instances-available-in-south-america/